Analysis of miRNA expression profile with metformin treatment in high glucose-induced HUVECs (¬n = 3) (A) The differential expression of miRNAs in high glucose-induced HUVECs treated with metformin, showing both up-regulated (red) and down-regulated (blue) miRNAs; (B) a volcano plot displaying the fold change of miRNA expression in the samples (log2 fold change) with their statistical significance (-log10 (p-value)), color-coded to distinguish the significantly upregulated (red), downregulated (blue), and n

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